![]() The first line treatment for a ganglioglioma is surgery, which if successful will be enough to have removed the tumour altogether. What is the treatment for a ganglioglioma? ![]() However, most gangliogliomas tumours develop independently of any genetic syndrome and you will be tested to clarify whether this is the case. What are the risk factors for gangliogliomas?Ĭhildren with certain genetic syndromes, including neurofibromatosis 1 and tuberous sclerosis, are at higher risk of developing gangliogliomas and other types of gliomas. Surgery to reduce tumour size and ideally remove the tumour usually helps to reduce or completely remove the seizures. However it is common to experience seizures with this tumour type, so anti-seizure medication will be prescribed for the patient to help control these. What are the symptoms of a ganglioglioma?Ī ganglioglioma can cause any of the symptoms usually associated with a brain tumour, listed here, depending on where it occurs in the brain. More than 95% gangliogliomas are low-grade and usually do not recur after removal, so the prognosis for these tumours that can be completely removed is often a cure.įor the remaining 5% of ganglioglioma patients these tumours will be more challenging to treat, but no definite prognosis can be established due to the rarity of this situation.įactors such as tumour location, how much of the tumour can be removed using surgery, and the range of genetic alterations and/or epigenetic differences (which affect the way that genes behave) are most likely to influence the variability in symptoms and outcome for patients with ganglioglioma. What is the prognosis for a ganglioglioma? Unfortunately this may mean that the tumour is more likely to be aggressive or higher grade than those tumours without this mutation. This is also found in other types of gliomas, for example in over 80% of IDH-mutant astrocytoma tumours. The presence of a tumour protein (tp) p53 mutation may be found in the glial cells of a ganglioglioma. Drugs that focus on influencing this BRAF V600E mutation are currently being developed as potential new treatments for a range of gliomas. This mutation does not seem to correlate with any particular pattern of ganglioglioma progression or the likelihood of recurrence, but may provide a useful target for treatments. Identification of a genetic mutation called BRAF V600E has been found in approximately 10% - 60% of gangliogliomas, but is not specific to this tumour type and is also found in a range of other types of glioma brain tumours. Genetic profiling of ganglioglioma brain tumours This type of tumour tends to recur after surgery, so radiotherapy and chemotherapy would be used to help control the progression, in the same way that it would be for other types of grade 3 gliomas. ![]() At this stage they would be considered cancerous. When this happens, they are reclassified as a grade 3 glioma because they have become more aggressive and more difficult to treat. Unfortunately in rare cases the glial cells within a ganglioglioma can transform to a higher grade. When the tumour is simple to remove completely and does not grow back, it may be referred to as benign or non-cancerous. Gangliogliomas are usually classified as a grade 1 or 2 glioma brain tumour, which means that they are a form of “low-grade” cancer that grows very slowly and does not spread to other parts of the body. Gangliogliomas are rare, accounting for approximately 1% - 2% of all brain tumours. How common are ganglioglioma brain tumours? Who can be diagnosed a ganglioglioma?Īlthough gangliogliomas have been reported in people of all ages, they are most commonly diagnosed in children and young adults. There are occasional reports of ganglioglioma occurring in the cerebellum, brainstem and spinal cord, which are at the back and base of the brain, running down into the spine. In this position these tumours tend to cause epilepsy, so a seizure may be the first sign that a ganglioglioma is present. Gangliogliomas often present in a temporal lobe: we have two temporal lobes, one on each side of the brain around the region of the ear. Where do ganglioglioma tumours appear in the brain? Glial cells are those that form the structure of the brain and interact closely with the neurons, nourishing them and helping them to function correctly.ĭiscover more about mixed neuronal-glial tumours. Neuronal cells are those that form the neurons in the brain, which primarily carry information. Ganglioglioma is a very rare type of glioma brain tumour that contains a mixture of neuronal and glial cells, and hence is part of a group of tumours classified as mixed neuronal-glial tumours. What is a ganglioglioma (GGL) brain tumour?
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |